Ultrasmall Au(10-12)(SG)(10-12) nanomolecules for high tumor specificity and cancer radiotherapy.
نویسندگان
چکیده
Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12 (SG)10-12 ) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
منابع مشابه
Ultrasmall Glutathione-Protected Gold Nanoclusters as Next Generation Radiotherapy Sensitizers with High Tumor Uptake and High Renal Clearance
Radiotherapy is often the most straightforward first line cancer treatment for solid tumors. While it is highly effective against tumors, there is also collateral damage to healthy proximal tissues especially with high doses. The use of radiosensitizers is an effective way to boost the killing efficacy of radiotherapy against the tumor while drastically limiting the received dose and reducing t...
متن کاملDetermining rectal dose through cervix cancer radiotherapy by 9 MV photon beam using TLD and XR type T GAFCHROMIC® Film
Background: The goals of the present research were to investigate the rectal dose during four chosen techniques of cervical cancer radiotherapy and to examine how accurately the treatment planning represents dose measurements, and it’s practicality for routine use as well as, to determine the homogeneity of dose in tumor volume. Materials and Methods: The study was carried out using a Nepton 10...
متن کامل(AuAg)144(SR)60 alloy nanomolecules.
(Au-Ag)(144)(SR)(60) alloy nanomolecules were synthesized and characterized by ESI mass spectrometry to atomic precision. The number of Ag atoms can be varied by changing the incoming metal ratio and plateaus at ∼60. UV-vis data demonstrates that the electronic structure of the nanomolecules can be tuned by incorporation of silver atoms. Based on the proposed 3-shell structure of Au(144)(SR)(60...
متن کاملIntraoperative radiotherapy (IORT) induced key molecular pathways in tumor bed of breast cancer patients: a pilot study
Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function of IORT. Materials and Methods: Six Breast Cancer (BC) patients as a pilo...
متن کاملImprovement of dose delivery with loading of tumor with gold nanoparticles in orthovoltage radiotherapy
Introduction: To enhance the dose to tumor, the use of high atomic number elements has been proposed. Objective: The aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic X-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (GNPs)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advanced materials
دوره 26 26 شماره
صفحات -
تاریخ انتشار 2014